What may cause the heart to ache?!

Question: What may cause the heart to ache!?
Answers:

cheating!.!.!.!.Www@Enter-QA@Com

Too many burgers!?Www@Enter-QA@Com

death of a loved oneWww@Enter-QA@Com

when i eat too much muffins out of sadnessWww@Enter-QA@Com

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