Alzheimer's disease... Is it hereditary?!


Question: Alzheimer's disease!.!.!. Is it hereditary!?
Answers:
If you are a child, brother or sister of someone with Alzheimer's disease, your risk of developing the disease depends on how old your relative was when the disease started!. If your relative developed Alzheimer's disease later in life, say after 65 years, your risk is only slightly higher than of anyone else in the general population!. Your risk is much higher, 25%, if you have two generations of first degree relatives who developed the disease before the age of 65!. If your affected relative is more distant, eg!. a grandparent, cousin or aunt, your risk is about the same a the general population!.Www@Enter-QA@Com

Is Alzheimer's disease hereditary!?

Familial Alzheimer’s disease (FAD) or early-onset Alzheimer’s is an inherited, rare form of the disease, affecting less than 10 percent of Alzheimer’s disease patients!. FAD develops before age 65, in people as young as 35!. It is caused by one of three gene mutations on chromosomes 1, 14 and 21!. If even one of these mutated genes is inherited from a parent, the person will almost always develop FAD!. All offspring in the same generation have a 50/50 chance of developing FAD if one parent has it!.

The majority of Alzheimer’s disease cases are late-onset, usually developing after age 65!. Late-onset Alzheimer’s disease has no known cause and shows no obvious inheritance pattern!. However, in some families, clusters of cases are seen!. Although a specific gene has not been identified as the cause of late-onset Alzheimer’s disease, genetic factors do appear to play a role in the development of this form of the disease!. A gene called Apolipoprotein E (ApoE) appears to be a risk factor for the late-onset form of AD!. There are three forms of this gene: ApoE2, ApoE3 and ApoE4!. Roughly one in four Americans has ApoE4 and one in twenty has ApoE2!. While inheritance of ApoE4 increases the risk of developing AD, ApoE2 substantially protects against the disease!. Scientists believe that several other genes may influence development of Alzheimer’s disease!. Two of these genes, UBQLN1 and SORL1, are located on chromosomes 9 and 11!. Researchers have also identified three genes on chromosome 10, one of which produces an insulin degrading enzyme that may contribute to the disease!.

Genetic risk factors alone are not enough to cause the late-onset form of Alzheimer’s disease, so researchers are actively exploring education, diet and environment to learn what role they might play in the development of this disease!. Www@Enter-QA@Com

It is!.

But there are different types which have different levels of heritability!. also, keeping healthy / fit and doing lots of mental exercises (like learning languages, crosswords, puzzles) can slow down the progression or lower your chances of getting Alzheimer's!.
I learnt this at uni!.
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I know that if somebody in your family has it, it increases your chances!. So yes I'd say it's hereditary, although they don't have a clue what causes it!.Www@Enter-QA@Com

It is very hereditary!.

It's an extremely sad disease too!.
my grandma died from it a few years ago, she didn't remember anyone in the family and she started going crazy!.
it was a sad thing to watch her go through!.Www@Enter-QA@Com

hi
mi
farandWww@Enter-QA@Com

Yes, I believe so!. My grandmother had it and it was hard dealing with her!.Www@Enter-QA@Com

yes it isWww@Enter-QA@Com

it is!.Www@Enter-QA@Com



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